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CILTEP is a natural nootropic that combines artichoke extract and forskolin to naturally induce long-term potentiation. Formulated by its creator Abelard Lindsay, CILTEP is a healthy way to stay focused, alert, and motivated for hours.

The benefits include:

  • Increased motivation and mental endurance
  • Increased ability to study and retain information
  • Improved concentration and long-term memory
  • Improved mood and social ease

CILTEP is used every day by thousands of people around the world, including CEOs, Wall Street Executives, college students, scientists and creatives. 

Users typically experience results for 8-14 hours. One bottle contains 60 capsules.

CILTEP Nootropic Stack - 60 ct. has a rating of 4.5 stars based on 46 reviews.

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Long-Term Potentiation
CILTEP works by naturally inducing Long-Term Potentiation (LTP), one of the major cellular mechanisms behind learning and memory. Memories are formed or “encoded” in the brain by creating LTP.
Premium Artichoke Extract
Artichoke extract contains Luteolin, a safe natural inhibitor of PDE4. PDE4 inhibitors have been shown to have significant nootropic effects including increased cognition, improved long term memory, increased wakefulness, and neuroprotection.
Forskolin Derived from Coleus Forskohlii
Forskolin activates the enzyme adenylyl cyclase which increases intracellular levels of cAMP. The result is an overall improvement of cognitive function, especially memory formation and retention of new information.
"I am seriously impressed with CILTEP"
"CILTEP has earned a place alongside world-class smart drugs like piracetam, gingko, and choline. It works synergistically with them to help you do – and be – more." - Dave Asprey, The Bulletproof Executive


"CILTEP has been by far the most impressive nootropic I’ve ever tried, period."

"If you’ve never tried nootropics before, or have, and noticed meager results, then CILTEP might be worth a try. Unlike most racetams, the effects are rapid and extremely noticeable."

- Chad Barnsdale

"The perfect tool to boost performance and enhance focus for students"

"I was skeptical, as many would be; but after taking the stacks once, then twice, then a third time it was clear that the hype surrounding Natural Stacks is real."

- Zack Huhn, Founder

"Artichoke extract and forskolin has an incredible cognitive effect"

"I've actually found it more effective than modafinil. This a stack that was developed by Abelard Lindsay"

- Tim Ferriss, Entrepreneur, Author and Investor

"I don't want to jump the gun, but honestly it worked instantaneously."

"Not sure if it’s supposed to affect the system as fast as it did, but I had clear focus all morning. It’s been a very productive day, full of reading, writing, and planning for new projects. "

- Alex West, Filmmaker

CILTEP works by naturally inducing Long-Term Potentiation.

Long-Term Potentiation (LTP) is a long lasting enhancement in signal transmission between two neurons that results from stimulating them both at the same time.[1]  LTP is one of the major cellular mechanisms behind learning and memory.[1][2]  Memories are formed or “encoded” in the brain by creating LTP.

CILTEP achieves LTP by: 1. Inhibiting Phosphodiesterase-4 (PDE4), and 2. Increasing cyclic adenosine monophosphate (cAMP).


PDE4 is an enzyme that breaks down cAMP molecules, messenger systems that relay signals in the brain. Inhibition of PDE4 blocks the breakdown of cAMP, thereby increasing levels of cAMP within brain cells. PDE4 inhibitors have been shown to have significant nootropic effects including increased cognition [3], improved long term memory [4], increased wakefulness [5], and neuroprotection.[6] [7]

Artichoke Extract is the safest and most effective PDE4 Inhibitor. There are other herbal supplements that can also perform PDE4 Inhibition but they have all been found to have significant side effects. CILTEP has 900 mg of the highest quality Artichoke Extract in each serving.


An herbal supplement named Forskolin (active compound extracted from the root of the Coleus Forskohlii plant) is the only known supplement to naturally increase cAMP levels. It activates the enzyme adenylyl cyclase which then increases intracellular levels of cAMP. CILTEP features premium Coleus Forskohlii standardized for 20% Forskolin. There are 4 mg of Forskolin in each serving of CILTEP.

Increasing cAMP and inhibiting its degradation (through PDE4 Inhibition) induces Long-Term Potentiation (LTP). The result is a significant overall improvement in cognitive function, especially memory formation and retention of new information.

Summary: PDE4 Inhibition + Increasing cAMP → LTP → Learning and Memory


CILTEP makes normal dopamine metabolism more effective at triggering the motivation, learning, and memory processes.[8] Meanwhile the chemical dynamics of the dopamine system are preserved, avoiding the negative side effects associated with using traditional dopamine stimulation (such as Adderall or Ritalin).

Research has shown that increased intracellular cAMP increases the rate of dopamine and acetylcholine synthesis.[9, 10]  L-Phenylalanine, L-Carnitine, and Vitamin B6 are included in the CILTEP formula to maintain optimal neurotransmitter levels.

L-Phenylalanine and L-Carnitine are amino acids found in some foods that the brain uses to make dopamine [11] and acetylcholine.[12] These natural nutrients synergize perfectly with Artichoke Extract and Forskolin, preventing fatigue and creating long lasting results with a lift in mood.


For an additional boost in drive and focus, moderate doses of natural stimulants stack very well with CILTEP. Certain types of tea and coffee may work but SMART CAFFEINE is ideal for achieving optimal alertness without the nervousness and jitters from regular caffeine sources. Be extremely cautious with stimulants because CILTEP magnifies their effects.

1. Plasticity in the human central nervous system.

2. A synaptic model of memory: long-term potentiation in the hippocampus.

3. Selective phosphodiesterase inhibitors: a promising target for cognition enhancement.

4. Rolipram, a type IV-specific phosphodiesterase inhibitor, facilitates the establishment of long-lasting long-term potentiation and improves memory.

5. Rolipram, an antidepressant that increases the availability of cAMP, transiently enhances wakefulness in rats.

6. Rolipram reduces excitotoxic neuronal damage.

7. Broad spectrum neuroprotection profile of phosphodiesterase inhibitors as related to modulation of cell-cycle elements and caspase-3 activation.

8. Amphetamine modulation of long-term potentiation in the prefrontal cortex: dose dependency, monoaminergic contributions, and paradoxical rescue in hyperdopaminergic mutant.

9. Sustained phosphorylation of tyrosine hydroxylase at serine 40: a novel mechanism for maintenance of catecholamine synthesis.

10. Forskolin, an inducer of cAMP, up-regulates acetylcholinesterase expression and protects against organophosphate exposure in neuro 2A cells.

11. Effect of vitamin B-6 nutrition on the levels of dopamine, dopamine metabolites, dopa decarboxylase activity, tyrosine, and GABA in the developing rat corpus striatum.

12. Acetyl-L-carnitine: from a biological curiosity to a drug for the peripheral nervous system and beyond.X

Motivation. Concentration. Memory.

Suggested Use: For optimal mental performance, take a serving of 2-3 capsules immediately upon waking on an empty stomach. Do not take more than 3 capsules per day.

Some users find that a moderate dose of caffeine in the morning and/or early afternoon extends and optimizes results (We recommend SMART CAFFEINE).

CILTEP can be taken daily, however we advise taking 1-2 days off per week (weekends for example).

U.S.A manufactured in a GMP facility. Natural Stacks proudly uses only the highest quality ingredients.

Artichoke Extract

Artichoke Extract contains Luteolin which is a natural inhibitor of the enzyme PDE4. This enzyme is present in neurons where it breaks down CREB activating cAMP. CREB activation is important for long-term potentiation, a process vital to learning and memory. Inhibiting PDE4 and thus increasing cAMP levels in neurons has been shown to increase long-term potentiation.


Forskolin is derived from the plant Coleus forskohlii and is used in traditional Indian Ayurvedic medicine. It has the property of increasing levels of cAMP in cells. Combined with Luteolin from Artichoke extract, forskolin synergistically increases the duration and levels of cAMP in neurons.


L-Phenylalanine is an essential amino acid present in many foods. When CREB is activated studies have shown that transcription of the enzyme tyrosine hydroxylase is increased leading to an increased rate of dopamine metabolism . L-Phenylalanine is the natural precursor to dopamine and thus helps supply the necessary amino acid fuel for that metabolism.

Acetyl-L-Carnitine (ALCAR)

ALCAR is an acetylated form of the amino acid L-Carnitine. L-Carnitine is present in many foods but can also be synthesized in the liver. When cAMP is increased in neurons by forskolin, studies have shown that levels of acetylcholinesterase are also increased. We added ALCAR to the stack to help mitigate the effects of increased acetylcholinesterase on short-term memory and energy.

Vitamin B6

Vitamin B6 is an essential vitamin and an important enzymatic cofactor that helps the body produce essential neurotransmitters including dopamine, serotonin, and GABA. It helps activate DOPA decarboxylase, an enzyme directly downstream from tyrosine hydroxylase in dopamine metabolism and thus helps to maintain optimal dopamine metabolism under conditions of increased Tyrosine Hydroxylase that occur during CREB enhanced LTP.


The official CILTEP White Paper written by Abelard Lindsay and released exclusively by NaturalStacks.com contains a detailed summary of the scientific research studies supporting CILTEP.

Download The Ciltep Whitepaper »

"The History of the CILTEP Stack"


  • Abelard Lindsay begins brain hacking.


  • Abelard joined Longecity.org back when it was called Immortality Institute.


  • Abelard started researching PDE4 Inhibitor/Forskolin connection.
  • Abelard started taking Luteolin in the form of Artichoke Extract with Forskolin.  Results were so good that he had trouble believing that he wasn’t going to have some sort of negative reaction or tolerance.


  • After several months of trials with only positive results Abelard reveals the Artichoke and Forskolin stack on the Longecity.org forum. (LINK)
  • Abelard named the stack “CILTEP”.
  • Interest in CILTEP begins to skyrocket on Longecity.org.
  • The first stack FAQ/Summary was created.
  • Abelard began experiments with Quercetin and other PDE4 inhibitors, which were later abandoned.
  • L-Phenylalanine was added to the stack.
  • Tim Ferriss mentions Artichoke Extract and Forskolin stack at Google Tech Talk. (LINK)


  • Longecity.org thread reaches 100,000 views. (LINK)
  • Tim Ferriss mentions Artichoke Extract and Forskolin stack on Joe Rogan show #320. (LINK)
  • Abelard recommended that Vitamin B6 be added to the stack. (LINK)
  • Abelard started experimenting with Zembrin and Kanna. He had fantastic results but made me a little too hyper-focused on studying.
  • Tim Ferriss mentions Artichoke Extract and Forskolin stacks on “The random show #21” and credits Abelard Lindsay as the inventor. (LINK)
  • Abelard announced that his research on CILTEP is open source.
  • Natural Stacks and Abelard start collaboration on producing a CILTEP product.
  • Acetyl-L-Carnitine was added to the stack to combat ACHE upregulation. (LINK1, LINK2)
  • Longecity.org thread reaches 350,000 views.
  • Abelard joins the Natural Stacks team as Director of Research & Development. (LINK)
  • Natural Stacks releases the worlds first and only CILTEP product. (LINK)


Do not consume nicotine or prescription stimulants with CILTEP. Do not use if pregnant, nursing, or under the age of 18. Consult with a healthcare practitioner before taking this or any nutritional supplement if you have or suspect a medical condition, are taking any medications, or other non-Natural Stacks dietary supplements.

What is CILTEP?

CILTEP is a natural nutritional supplement designed for improving and maintaining brain performance. It's theorized to improve learning and memory in the brain by supporting and optimizing levels of intracellular secondary messengers.

Are there any side effects?

There are no known side effects if used as directed. For that reason, thousands of people have chosen all-natural CILTEP as their preferred nootropic stack.  

Is CILTEP FDA approved?

Dietary supplements are not reviewed and approved by the Food and Drug Administration (FDA).  CILTEP is an over the counter dietary supplement and does not require FDA approval, but CILTEP is quality-tested, manufactured, and packaged in FDA registered facilities.

Is CILTEP regulated by the FDA?

As a dietary supplement CILTEP's package labeling, ingredients, and manufacturing quality are regulated by the FDA pursuant to the Federal Food, Drug and Cosmetic Act.

How is the product shipped from NaturalStacks.com?

We proudly offer FREE regular ground shipping for all order from the United States. We offer 3 shipping options:

  • United States – FREE  - Regular Ground Shipping (3-5 days)
  • United States – $20 - Expedited Air Shipping (2-3 days)
  • International – $9.95 - Regular Shipping (6-15 days)

Shipments are made Monday through Friday. Weekend delivery is not available. All "Regular" shipments are sent via USPS First Class Mail. International orders to some countries may take longer than 15 days and may be subject to duties and/or taxes.

Is there a money back guarantee?

Yes! All orders purchased through NaturalStacks.com are backed by our 30-day 100% money back guarantee from the date of purchase. If in the unlikely event you are not completely satisfied with your purchase, you can return your product for a refund. Shipping & handling charges and additional opened products after the first bottle are not refundable.

Open Source

Open Source

It’s your right to know what exactly you’re putting into your body.

Most companies use “proprietary blends” so they don’t have to tell you the amount of each ingredient in their formulas. It’s a shady and sometimes dangerous practice. At Natural Stacks we proudly publish our innovative formulas in an open source format.
Premium Quality

Premium Quality

Each ingredient has a defined biomechanical purpose.

Natural Stacks formulas contain ingredients which are carefully selected solely on the basis of quality and purity. We actively seek out the most bioavailable forms of each ingredient, and avoid the cheap synthetic forms used by the majority of supplement companies.
Made in the USA

Made in the USA

Anywhere else is a compromise that we refuse to make.

All Natural Stacks products are manufactured under the guidelines of the United States Pharmacopoeia (U.S.P.) and Current Good Manufacturing Practices (c.G.M.P.) in an FDA registered facility that is licenced by the U.S. Department of Health and Human Services.
Unrivaled Support

Unrivaled Support

Buy with confidence the first time and every time.

If for whatever reason you’re unsatisfied with your purchase, our customer service champions will work with you to make it right. We also regularly provide actionable tips on our blog and support in our community forum. Admittedly we’re a little obsessed with helping you #liveoptimal.
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