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CILTEP® Nootropic Stack

For Mental Performance
For Mental Performance

CILTEP® is a natural nootropic designed to safely enhance the brain's ability to form vivid, long-lasting memories and remain sharply motivated and focused for hours.

Users of CILTEP® often report:

  • Increased motivation and mental endurance†
  • Improved concentration and alertness†
  • Improved mood and social ease†
  • Enhanced ability to study†

CILTEP® is used every day by thousands of people around the World, including CEOs, Wall Street Executives, college students, scientists and creatives. 

Fast FREE U.S. shipping for a limited time only.

Increased focus and mental sharpness

Increased motivation and mental endurance

Enhanced sense of novelty, presence, and awareness

Improved recall and memory formation

Ingredients

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Artichoke extract contains Luteolin, a natural inhibitor of PDE4 [1,2]. PDE4 is an enzyme that breaks down cAMP molecules, messenger systems that relay signals in the brain. Studies have correlated lower levels of the enzyme PDE4 to significant increases in normal mental performance, including increased cognition [3], improved long term memory [4], increased wakefulness [5], and neuroprotection. [6,7,8]

Read More About Artichoke Extract

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Forskolin is derived from the plant Coleus forskohlii which has been widely used in traditional Ayurvedic medicine [9]. It has also has been extensively studied due to it’s ability to increase levels of intracellular cAMP molecules [10]. Combined with Luteolin from Artichoke Extract, forskolin is theorized to synergistically increase the duration of cAMP in neurons. *

Read More About Forskolin

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Vitamin B6 is an essential vitamin and an important enzymatic cofactor in normal metabolic and psychological function. [11] CILTEP features the metabolically active form of Vitamin B6 for optimal bioavailability (Pyridoxal-5-Phosphate).

Read More About Vitamin B-6

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Acetyl-L-Carnitine, or ALCAR, is an acetylated form of the amino acid L-Carnitine that has been shown to cross the blood brain barrier. [14]. Known for its roles in energy metabolism and mitochondrial protection, the addition of ALCAR to the CILTEP formula helps combat feelings of brain fog and fatigue. [15,16]

Read More About Acteyl-L-Carnitine

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An essential building block for the neurotransmitter dopamine, L-Phenylalanine is an essential amino acid that can be found in protein-rich foods like meat, eggs, spinach and other leafy greens. [12,13]

Read More About L-Phenylalanine

Artichoke Extract

900 mg

Artichoke extract contains Luteolin, a natural inhibitor of PDE4. PDE4 is an enzyme that breaks down cAMP molecules, messenger systems that relay signals in the brain. PDE4 Inhibitors have been shown to have significant nootropic effects including increased cognition [5], improved long term memory [6], increased wakefulness [7], and neuroprotection.[8] [9]

Forksolin

20 mg

Forskolin is derived from the plant Coleus forskohlii which has been widely used in traditional Ayurvedic medicine [9]. It has also has been extensively studied due to it’s ability to increase levels of intracellular cAMP molecules [10]. Combined with Luteolin from Artichoke Extract, forskolin is theorized to synergistically increase the duration of cAMP in neurons. *

Vitamin B-6

5 mg

Vitamin B6 is an essential vitamin and an important enzymatic cofactor in normal metabolic and psychological function. [11] CILTEP features the metabolically active form of Vitamin B6 for optimal bioavailability (Pyridoxal-5-Phosphate).

Acetyl-L-Carnitine

750 mg

Acetyl-L-Carnitine, or ALCAR, is an acetylated form of the amino acid L-Carnitine that has been shown to cross the blood brain barrier. [14]. Known for its roles in energy metabolism and mitochondrial protection, the addition of ALCAR to the CILTEP formula helps combat feelings of brain fog and fatigue. [15,16]

L-Phenylalaline

500 mg

An essential building block for the neurotransmitter dopamine, L-Phenylalanine is an essential amino acid that can be found in protein-rich foods like meat, eggs, spinach and other leafy greens. [12,13]

Suggested Use

Take 1-3 capsules in the morning immediately upon waking on an empty stomach, or as directed by a healthcare practitioner. Do not take more than 3 capsules per day.

Some users find that a moderate dose of caffeine in the morning and/or early afternoon extends and optimizes results (We recommend SMART CAFFEINE®).

CILTEP® can be taken daily, however we advise taking 1-2 days off per week (weekends for example).

U.S.A manufactured in a GMP facility. Natural Stacks proudly uses only the highest quality ingredients.

CILTEP® is protected under U.S. Patent 9,149,547

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How It Works

CILTEP® is a natural nootropic supplement that helps the user achieve a high state of focus and concentration and enhanced memory formation. CILTEP® is designed to induce long-term potentiation (LTP) in the brain, which is a crucial mechanism involved in the formation of new memories and the strengthening of neural synapses in the brain.

Chemically-induced long-term potentiation (CILTEP®) refers to the activation of LTP through the use of ingredients like artichoke extract, forskolin, select vitamins and amino acids that work synergistically to increase levels of cAMP, a messaging system that relays signals in the brain. Elevated cAMP levels in the brain are known to induce LTP and are associated with improved memory, concentration, and memory formation.

PDE4 INHIBITION

PDE4 is an enzyme that breaks down cAMP molecules, messenger systems that relay signals in the brain. Inhibition of PDE4 blocks the breakdown of cAMP, and thereby increases levels of cAMP within brain cells.

This has been shown to lead to increased cognition, improved long term memory, increased wakefulness, and neuroprotection. [3,4,5,6,7,8]

There have been several natural PDE4 inhibitors identified in herbal preparations including luteolin, which is present in artichoke extract. It also inhibits PDE 1 through 5 which have both shown beneficial activity with regards to synaptic plasticity. [1,2]

Artichoke Extract is a safe, effective and natural PDE4 Inhibitor. [1,2] CILTEP contains 900 mg of the highest quality Artichoke Extract in each serving.

ADDITIONAL BOOST

For an additional boost in feelings of drive and focus, moderate doses of coffee or tea stack very well with CILTEP. Certain types of tea and coffee may work but SMART CAFFEINE is ideal for achieving optimal alertness without the jittery feeling from regular caffeine sources. [19] Be extremely cautious with stimulants because CILTEP may magnify their effects.

INCREASING cAMP

The herb Forskolin (active compound extracted from the root of the Coleus Forskohlii plant) has been shown to naturally increase cAMP levels. It activates the enzyme adenylyl cyclase which then increases intracellular levels of cAMP. [10]

CILTEP features premium Coleus Forskohlii standardized for 20% Forskolin. There are 4 mg of Forskolin in each serving of CILTEP.

CILTEP is the first ever product to combine these two, has been awarded a US patent, and is currently involved in multiple placebo-controlled, double-blind University studies.

Increasing cAMP and inhibiting its degradation supports Long-Term Potentiation (LTP).

Summary: PDE4 Inhibition + Increasing cAMP → LTP → Supports optimal mental performance

Open Source

Most companies use "proprietary blends" so they don't have to tell you the amount of each ingredient in their formulas. At Natural Stacks we believe it's your right to know exactly what you're putting into your body. We proudly publish our innovative formulas and ingredient suppliers in an open source format.

Learn About Our Commitment To Transparency

Frequently Asked Questions

When should I take CILTEP®?

We suggest taking CILTEP first thing in the morning on days that include demanding cognitive tasks. Take it on an empty stomach and 20-30 minutes later, you eat breakfast or - our favorite, have some bulletproof coffee for an extra spark.

How does CILTEP work and what will I feel?

CILTEP increases focus and potentiates long-term memory but doesn't rely on neurotransmitter manipulation to elicit this benefit. Because CILTEP is not a stimulant and it doesn’t directly impact our neurotransmitters, the “feel” is very subtle.

What you notice most is that time seems to slow, distractions fade away (increased focus), and you have a strong desire to learn/read/work.

The more mentally demanding the task, the more CILTEP shines.

Many users prefer to “stack” or combine CILTEP with one of our Brain Food products. The Brain Food line is designed to give individuals the tools needed to optimize whatever neurotransmitter they may need to moderate on any given day or at any given time.

What is CILTEP®?

CILTEP is a natural nutritional supplement designed for improving and maintaining brain performance. It's theorized to improve learning and memory in the brain by supporting and optimizing levels of intracellular secondary messengers.

Are there any side effects?

There are no known side effects if used as directed. For that reason, thousands of people have chosen all-natural CILTEP as their preferred nootropic stack.

Do I have to cycle CILTEP?

We recommend to cycle off of it once a week but it’s not required.

I'm 16. Can I take CILTEP?

No, CILTEP should only be taken once you’re 18 years old.

Is CILTEP vegan?

Yes.

Is CILTEP soy free?

Yes.

When is the best time to take CILTEP?

Upon waking is the most desirable time to take CILTEP. Some people do enjoy taking CILTEP later in the day, but we recommend avoiding use in the afternoon / evening to maintain optimal sleep.

What makes CILTEP better / different than other smart drugs?

CILTEP uses a simple, all-natural formula that works by increasing the number of messenger systems inside of your brain cells. This enables neurons to quickly communicate with each other and retain information. It makes you more engaged and efficient at whatever mental task you might be doing.

CILTEP enhances your mental capacity without relying on altering neurotransmitter levels. It acts inside of the cell to naturally strengthen connections between neurons, promoting improved learning, memory, and cognitive function.

Citations & References

1. Brown JE, Rice-evans CA. Luteolin-rich artichoke extract. Free Radic Res. 1998;29(3):247-55. PMID 9802556 32

2. Yu MC, Chen JH, Lai CY, Han CY, Ko WC. Eur J Pharmacol. 2010;627(1-3):269-75. PMID 19853596

3. Rutten K, Van donkelaar EL, Ferrington L, et al. Neuropsychopharmacology. 2009;34(8):1914-25. PMID 19262466

4. Reneerkens OAH, Rutten K, Steinbusch HWM, Blokland A, Prickaerts J. A promising target for cognition enhancement. Psychopharmacology. 2009;202(1-3):419-443. doi:10.1007/s00213-008-1273-x.

5. Barad M, Bourtchouladze R, Winder DG, Golan H, Kandel E. Proc Natl Acad Sci USA. 1998;95(25):15020-5. PMID 9844008

6. Lelkes Z. Pharmacol Biochem Behav. 1998 Aug;60(4):835-9.

7. Block F1. Neuroreport. 2001 May 25;12(7):1507-11.

8. Chen RW. Neurosci Lett. 2007 May 17;418(2):165-9. Epub 2007 Mar 18.

9. Ammon HP, Müller AB. Forskolin: from an ayurvedic remedy to a modern agent. Planta Med. 1985;51(6):473-7. PMID 17345261

10. Seamon KB, Daly JW. Forskolin: a unique diterpene activator of cyclic AMP-generating systems. J Cyclic Nucleotide Res. 1981;7(4):201-24. PMID 627800

11. Linus Pauling Institute. Micronutrient Information Center: Vitamin B6. http://lpi.oregonstate.edu/mic/vitamins/vitamin-B6

12. Broadley KJ (March 2010). Pharmacol. Ther. 125 (3): 363–375. doi:10.1016/j.pharmthera.2009.11.005. PMID 19948186.

13. Lindemann L, Hoener MC (May 2005). "A renaissance in trace amines inspired by a novel GPCR family". Trends Pharmacol. Sci. 26 (5): 274–281. doi:10.1016/j.tips.2005.03.007. PMID 15860375.

14. Inano A1. Acetyl-L-carnitine permeability across the blood-brain barrier and involvement of carnitine transporter OCTN2. Biopharm Drug Dispos. 2003 Nov;24(8):357-65.

15. Scafidi S, Fiskum G, Lindauer SL, et al. Metabolism of acetyl-L-carnitine for energy and neurotransmitter synthesis in the immature rat brain. Journal of neurochemistry. 2010;114(3):820-831. doi:10.1111/j.1471-4159.2010.06807.x.

16. Pettegrew, JW. Molecular Pyschiatry. Nov. 2000, Volume 5, Number 6, Pages 616-632.

17. Cooke SF. Plasticity in the human central nervous system. Brain. 2006 Jul;129(Pt 7):1659-73. Epub 2006 May 3.

18. Bliss TV1. A synaptic model of memory: long-term potentiation in the hippocampus. Nature. 1993 Jan 7;361(6407):31-9.

19. Bryan J1. Psychological effects of dietary components of tea: caffeine and L-theanine. Nutr Rev. 2008 Feb;66(2):82-90. doi: 10.1111/j.1753-4887.2007.00011.x

20. Curtin BF. Forskolin, an inducer of cAMP, up-regulates acetylcholinesterase expression. Mol Cell Biochem. 2006 Oct;290(1-2):23-32. Epub 2006 Aug 19.

21. Guilarte TR. Neurochem Res. 1989 Jun;14(6):571-8.

22. White HL. Acetyl-L-carnitine as a precursor of acetylcholine. Neurochem Res. 1990 Jun;15(6):597-601.

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If for whatever reason you're unsatisfied with your Natural Stacks products, you can return the product within 30 days for a full refund. We also provide actionable tips on our blog and newsletter for you to maximize your performance with our premium products.

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*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

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