GABA Brain Food™

For Calmness & Relaxation
Rated 4.6 out of 5
79 Ratings

List Price: $44.00

$39.95

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Recommended
For Calmness & Relaxation
Rated 4.6 out of 5
79 Ratings

GABA Brain Food is designed to support the normal, healthy production of GABA, a neurotransmitter essential to mental calmness.

Research suggests that the natural compounds in GABA Brain Food may help reduce temporary feelings of stress, as well as promote relaxation and improve sleep.

  • Promotes feelings of calmness
  • Supports relaxation
  • Supports clear thoughts and calms one’s mind
  • Supports restful, restorative sleep

This natural formula contains the necessary precursors and cofactors for optimal GABA availability.

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GABA For Calm and Relaxation

GABA is a neurotransmitter which acts like a “brake” to keep excitation in check. Too much excitation can lead to irritability, restlessness, and sleep disruption to name a few. GABA’s role as the main inhibitory neurotransmitter helps provide this function in the human body.

GABA is what is known as a self-inhibiting compound. This means, when you take more GABA than your body needs, it blocks its own transport into the brain to maintain constant, normal GABA concentrations. To circumvent this mechanistic limitation, we included the ingredients L-Citrulline, Rosmarinic Acid, and Grape Seed Extract. These natural ingredients work synergistically to both increase GABA’s transport into the brain and work to sustain elevated concentrations of GABA.

Click here to view a diagram of how GABA Brain Food’s ingredients influences natural GABA metabolism.

The main challenge in increasing brain levels of GABA via supplementation is circumventing the molecule’s inherent self-inhibiting characteristic. It is suggested that increasing GABA’s permeability across the blood-brain barrier is an effective target to increase brain levels of GABA. One way to do this is to increase vasodilation by upregulating nitric oxide (NO) production in the body.

L-citrulline is a precursor to the amino acid, L-Arginine, which has a potent effect on stimulating NO production. Additionally, grape seed extract has been shown to increase the production of Endothelial Nitric Oxide Synthase (eNOS), an enzyme used to generate NO from L-Arginine.

Once GABA is made more permeable and able to freely cross the blood-brain barrier with increased NO production, it is naturally broken down by the enzyme GABA-Transaminase (GABA-T). To attenuate the degradation of GABA by GABA-T we incorporated rosmarinic acid into our formulation, which has an inhibitory effect on GABA-T, thus allowing for sustained, elevated levels of GABA in the brain for a longer period of time.

GABA

Gamma-Aminobutyric Acid is a naturally occurring neurotransmitter with central nervous system (CNS) inhibitory activity. Gamma-aminobutyric acid (GABA), converted from the principal excitatory neurotransmitter glutamate in the brain, plays a role in regulating neuronal excitability by binding to its receptors, GABA-A and GABA-B, and thereby causing ion channel opening, hyperpolarization and eventually inhibition of neurotransmission. [1]

GABA acts to slow down signals between neurons, making neurons less electrically excitable. [2]

Studies also show that It plays a role in neuronal stem cell differentiation, possibly giving it an important role in adult brain plasticity. [3]

L-Citrulline

Recently, research showed that with an increase in nitric oxide, GABA could more easily cross the blood brain barrier. Nitric oxide also causes GABA release in the hippocampus [4]. In a recent study, GABA supplementation by itself increased brain GABA 33%, but when combined with L-arginine, a stimulator of nitric oxide, brain GABA rose 383.3%. [5]

We chose to use L-Citrulline as the NO-booster in GABA Brain Food because it has been shown to be a more effective NO booster than L-Arginine [6,7,8,9]

Rosmarinic Acid

Rosmarinic acid, present in rosemary, lemon balm, and other herbal agents known for their calming properties, inhibits GABA-transaminase, which slows the breakdown of GABA [10]

Grape Seed Extract

Grape Seed Extract can also upregulate the eNOS enzyme for a further boost to nitric oxide [11]

The National Center for Complementary and Integrative Health (NCCIH) is currently supporting research and studies on other potential abilities of grape seed extract to support healthy cellular function. [12]



Ingredients

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As the main inhibitory neurotransmitter in the brain, GABA’s role is to act like a “brake” and balance excessive stimulation. GABA is associated with normal restful sleep, relaxation, tranquil thoughts, and a serenity of mind.

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An amino acid found in foods like watermelon, dairy, beef and pork. L-Citrulline is converted into L-arginine, a known nitric oxide booster, which is theorized to help shuttle GABA into the brain across the blood-brain barrier.

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Found in rosemary, sage, mint and basil, rosmarinic acid is a naturally occurring polyphenol flavonoid. It is also found in lemon balm and is used in aromatherapy to promote feelings of calm and relaxation.

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Similar to L-citrulline, grape seed extract is used to increase nitric oxide production to help GABA pass across the blood-brain barrier and enter the brain.

GABA

633mg

As the main inhibitory neurotransmitter in the brain, GABA’s role is to act like a “brake” and balance excessive stimulation. GABA is associated with normal restful sleep, relaxation, tranquil thoughts, and a serenity of mind.

L-Citruline

500mg

An amino acid found in foods like watermelon, dairy, beef and pork. L-Citrulline is converted into L-arginine, a known nitric oxide booster, which is theorized to help shuttle GABA into the brain across the blood-brain barrier.

Rosemary Extract

333mg

Found in rosemary, sage, mint and basil, rosmarinic acid is a naturally occurring polyphenol flavonoid. It is also found in lemon balm and is used in aromatherapy to promote feelings of calm and relaxation.

Grape Seed Extract

33mg

Similar to L-citrulline, grape seed extract is used to increase nitric oxide production to help GABA pass across the blood-brain barrier and enter the brain.

Suggested Use

Take a serving of 1 or 2 capsules as needed, or as directed by a healthcare practitioner.

U.S.A. manufactured in a cGMP facility. Natural Stacks proudly uses only the highest quality ingredients.

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Open Source

Most companies use "proprietary blends" so they don't have to tell you the amount of each ingredient in their formulas. At Natural Stacks we believe it's your right to know exactly what you're putting into your body. We proudly publish our innovative formulas and ingredient suppliers in an open source format.

Learn About Our Commitment To Transparency

The Brain Food™ Series

Dopamine Brain Food™

Dopamine Brain Food™

FOR MENTAL ALERTNESS

Responsible for motivation, memory, and creativity, dopamine is a key neurotransmitter that also increases alertness and assertiveness.

Learn More
Serotonin Brain Food™

Serotonin Brain Food™

FOR A POSITIVE MOOD

Designed to support the body's natural production of Serotonin, a neurotransmitter essential to mental well-being.

Learn More

Frequently Asked Questions

What is GABA?

Gamma-aminobutyric acid (GABA) is a neurotransmitter that blocks impulses between nerve cells in the brain. It is thought to be one of the most important chemicals responsible for reducing excess neural stimulation, among other functions.

What is GABA's Function?

The main function of GABA is to reduce activity in nerve cells and the nervous system. Research shows that when GABA levels are increased, there may be a positive natural calming effect in the brain. GABA's function is closely linked to many conditions such as depression, mood, anxiety, stress, and sleep.

Are GABA Supplements Safe?

GABA supplements are considered safe. 

Are there any side effects with GABA Supplements?

No, side effects from GABA supplementation are uncommon. No significant risks or side effects have been documented in the scientific literature.

What is GABA Brain Food used for?

GABA Brain Food is used to naturally increase the production and balance of the neurotransmitter GABA. Customers use GABA Brain Food to wind down from over-stimulation, stress, and anxiety. This formula is also used as a sleep aid, as GABA is the key neurotransmitter that helps us relax and prepare for restful sleep at night.

When should I take GABA Brain Food?

GABA Brain Food can be taken any time of day to support feelings of calmness, social ease, and relaxation. For best sleep results, we recommend taking a full serving of GABA Brain Food roughly one hour before bedtime.

Can GABA help me sleep?

Yes! In addition to its effects on mood and mental relaxation, GABA Brain Food acts as a one of a kind natural sleep aid. It can help improve sleep because GABA is the neurotransmitter that kick starts the sleep cycle.

It is important to note that GABA as an isolated compound is poorly absorbed by the brain. To improve upon this limitation, we formulated GABA Brain Food with a selection of key ingredients to effectively increase GABA's absorption into the brain, and to keep GABA levels sustained for longer periods of time.

Can I use GABA Brain Food with the rest of the Natural Stacks Brain Food line (Serotonin, Dopamine, Acetylcholine)?

Yes! GABA Brain Food was designed to work synergistically with the entire Natural Stacks Brain Food line of formulas. Acetylcholine and Serotonin stack naturally with GABA. 

Dopamine and GABA can be taken in the same day, but we don't recommend stacking them. Dopamine is used to increase stimulation in the brain, while GABA serves to decrease stimulation. For best results try taking Dopamine in the morning and GABA at night.

For powerful mood support try taking GABA with Serotonin

For smoother social interaction try taking GABA with Acetylcholine. 


How do my GABA receptors work?

GABA receptors are the "docking sites" in the brain that allow GABA molecules to bind and transmit chemical impulses. GABA works as the natural "key" to the GABA receptor's "lock," which is how inhibitory signals are transmitted between neurons.

What Natural Stacks work well with GABA Brain Food?

GABA Brain Food works well with many different Natural Stacks. 

Here are our favorites:

  • Prebiotic+ Resistant Starch
  • MagTech Magnesium Complex
  • BrainBiotic
  • Eye Defense

Money Back Guarantee

If for whatever reason you're unsatisfied with your Natural Stacks products, you can return the product within 30 days for a full refund. We also provide actionable tips on our blog and newsletter for you to maximize your performance with our premium products.

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User Reviews

average rating 4.6 out of 5
Based on 79 ratings
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98% of reviewers would recommend these products to a friend
Sense of Calm
Rated 4 out of 5
Improved Sleep
Rated 4 out of 5
Deeper Relaxation
Rated 4 out of 5
56 Reviews
Review posted
Rated 5 out of 5

Best supplements

NS supplements never disappoint me. I feel calmer and sleep better. I will reorder.

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Review posted
Rated 5 out of 5

S-L-E-E-P!

Finally, a Gaba that works!! I take two of these along with 3 MagTech's about an hour before bed. I get super relaxed and drowsy and can fall asleep much easier than I would otherwise. Also, the best part, is that I basically stay asleep the whole night, and feel more rested in a shorter amount of time. I assume that I'm falling into a deeper sleep for a longer period, but that's just my guess. Whatever the reason, it works, and I'm thrilled! Note: I have purchased Gaba from health food stores in powder form and mixed with drinks, etc and took it in the evening. It usually gave me a headache, and did nothing else, so I was very hesitant to try Gaba Brain Food, thinking that it would do the same thing. That's why I said finally a Gaba that works! It produces the result for me that I hear so many other people use Gaba for.

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Sense of Calm
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Review posted
Rated 4 out of 5

GABA daba doo!

This supplement is really helpful for my daughters. They have an easier time focusing, doing normal routines, being on an even keel during the day. They are trying to get off prescription meds and are making progress toward that end. GABA and serotonin are a great combination daily!

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Sense of Calm
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Rated 3 out of 5
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Review posted
Rated 5 out of 5

A must have!

Absolutely fantastic for chronic fatigue/brain fog! I noticed results right away & within a month was feeling better than have in many yrs!

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Improved Sleep
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Deeper Relaxation
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Review posted
Rated 5 out of 5

Let me tell you something..

I went from sleeping 2-3 hours a night on a good night, and thats total not even consistent. But with this GABA i now sleep 6 hours STRAIGHT and the dreams OH BOY they are back and better than ever!

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Citations & References

1. NIH. U.S. National Library of Medicine. GABA. Compound Summary for CID 5281792 Pub Chem. Open Chemistry Database.

2. Mccormick DA. GABA as an inhibitory neurotransmitter in human cerebral cortex. J Neurophysiol. 1989;62(5):1018-27. PMID 2573696

3. Salazar P, Velasco-velázquez MA, Velasco I. GABA effects during neuronal differentiation of stem cells. Neurochem Res. 2008;33(8):1546-57. PMID 18357524

4. Getting SJ, Segieth J, Ahmad S, Biggs CS, Whitton PS. Biphasic modulation of GABA release by nitric oxide in the hippocampus of freely moving rats in vivo. Brain Res. 1996;717(1-2):196-9. PMID 8738273

5. Boonstra E, De kleijn R, Colzato LS, Alkemade A, Forstmann BU, Nieuwenhuis S. Neurotransmitters as food supplements: the effects of GABA on brain and behavior. Front Psychol. 2015;6:1520. PMID 26500584

6. Examine: L-Citrulline. Examine.com

7. Kuhn, K. P., et al. Oral citrulline effectively elevates plasma arginine levels for 24 hours in normal volunteers. Circulation 2002; 106: II1–766S.

8. Schwedhelm, E., et al. "Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism," British Journal of Clinical Pharmacology, 65(1):51-9, 2008.

9. Stephen J. Bailey, et. al. L-Citrulline supplementation improves O2 uptake kinetics and high-intensity exercise performance in humans. J Appl Physiol 119: 385–395, 2015.

10. Awad R, Muhammad A, Durst T, Trudeau VL, Arnason JT. Bioassay-guided fractionation of lemon balm (Melissa officinalis L.) using an in vitro measure of GABA transaminase activity. Phytother Res. 2009;23(8):1075-81.PMID 19165747

11. Feng Z, Wei RB, Hong Q, Cui SY, Chen XM. Grape seed extract enhances eNOS expression and NO production through regulating calcium-mediated AKT phosphorylation in H2O2-treated endothelium. Cell Biol Int. 2010;34(10):1055-61. PMID 20513234

12. US Department of Health and Human Services. National Institute of Health Database. Grape Seed Extract. The National Center for Complementary and Integrative Health (NCCIH)

†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

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